Exercise: Required. Here are a few to help you start the conversation: Factor V is a coagulation factor, or protein, in your blood. During long car rides, stop every few hours and take a short walk. Do you know someone who has suffered a deep vein thrombosis, pulmonary embolism, or other type of venous blood clot? Gluten-free: The breads Pasternak allows are flour-free. Keep going to your follow-up appointments with your provider, especially if youre taking a blood thinner. You may substitute gluten-free alternatives as long as they are low-sugar. Fiber (whole-grain cereal, beans, wild rice, flourless wheat bread. You inherit this condition from one of your biological parents. Inheriting one copy slightly increases your risk of developing blood clots. About 1 of every 250 Black people in America has the prothrombin gene mutation. Retrieved on March 04, 2023 from https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. 3. At this time, we cant treat or change our genes. AskMayoExpert. Is this an emergency? . In this interview, we speak to Ceri Wiggins, a Director at AstraZeneca, about the many applications of CRISPR and its role in discovering new COPD therapies. This site complies with the HONcode standard for trustworthy health information: verify here. One of these factors is Factor V (FV) Leiden (rs6025), which is a missense variant caused by a single nucleotide polymorphism (SNP) in the F5 gene. There are 2 copies for Factor V gene, which are passed down from our parents. If you have Factor V Leiden, you have a greater chance of developing blood clots. Factor V Leiden and prothrombin gene mutations cause about 50% of inherited coagulopathies. If you have other chronic conditions such as diabetes, work with your health team to manage your health. Factor V is a helper in the enzyme reactions that form the fibrin in the clot. Yes, you may be able to donate blood if youre not taking a blood thinner. Build physical activity into your daily life. Laboratory testing (blood tests) diagnose this disorder. You may be treated with blood thinners during this time. When you are ready, talk with your health care provider for advice and help to lose weight. 0000008374 00000 n Avoid foods high in vitamin k (leafy greens mostly), certain supplements, and avoid consuming too much alcohol. you have a medical emergency, call 911 immediately. If you have factor V Leiden and have developed blood clots, anticoagulant medications can lessen your risk of developing additional blood clots and help you avoid potentially serious complications. 0000239923 00000 n Leg wraps that inflate and deflate to keep blood moving in your legs. And it provides simple recipes that promise no more than 5 ingredients and 5 minutes of prep time. All rights reserved. 0000007946 00000 n This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Regular noncontact exercise, such as walking or swimming, is still recommended for good health. If you have factor V Leiden, you may have many questions. Children who are healthy and do not have factor V Leiden will get a blood clot in one out of 50,000-100,000 . https://www.uptodate.com/contents/search. For instance, they may work faster or slower, more or less effectively, or cause digestive problems. Tenderness or pain in your leg or arm, which you may only feel when standing or moving around. As a result, your blood may clot more easily than it should, leading to serious complications. She maintains a focus on anxiety disorders and depression and aims to explore other areas of mental health including dissociative disorders such as maladaptive daydreaming. Bauer KA. Accessed June 4, 2018. 1, 2 This Cardiology Patient Page will describe deficiencies in the natural anticoagulants, protein C, protein S, and antithrombin that may result in either professional diagnosis, opinion, treatment, or services to you or any individual. Signs of DVT: swelling or redness of your leg, with pain in your calf or inner thigh, Signs of PE: chest discomfort or shortness of breath. It is not a disease. Vitamin K antagonists (VKAs) are the most commonly prescribed oral anticoagulants worldwide. Factor V is a protein or clotting factor that helps create the enzyme reactions that form the fibrin in the clot. Eat well. Accessed June 4, 2018. Your provider will advise you on whether you need testing, as well as on the pros and cons of testing. Limited sodium: Get less than 2,300 mg of sodium daily, per the American Heart Association. There are many foods that can be beneficial to the health of patients with Factor V Leiden. Hereditary thrombophilia. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. There currently arent any genetic treatments that can stop someone from inheriting a mutated F5 gene. Anticoagulants and vitamin K interactions, Anticoagulants and herbal supplement and vitamin interactions, No benefit of low dose apixaban following acute COVID-19, Study finds fractionation of sulfated galactan from red alga can isolate its anti-SARS-CoV-2 properties, Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients. Talk with your doctor about the risks and benefits of taking these medications. How experienced is the lab at performing this test? National Heart, Lung, and Blood Institute. Factor V that becomes impaired can cause numerous issues with the health of the human blood. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). This can be a life-threatening situation. Factor V Leiden doesnt affect life expectancy in most people. Signs and symptoms may include: Seek medical attention immediately if you have signs or symptoms of either a DVT or a pulmonary embolism. 76 0 obj<> endobj Most notably, you will need to be aware of your vitamin K consumption. The latest information about heart & vascular disorders, treatments, tests and prevention from the No. Study Results Demonstrate VTE Treatment Satisfaction Among Patients, Managing Anticoagulants Before, During, and After Medical Procedures, Helping Women Make Choices About Contraception Following DVT Blood Clots, Panel Discussion: Blood Clots & Womens Health, Frequently Asked Questions: COVID-19 and Blood Clotting, Stop the Clot, Spread the Word Hospitalization, Toolkit for Knee and Hip Replacement Patients, Health Disparities and the VTE Mississippi Initiative, Atrial Fibrillation (AFib) and Clot-Provoked Stroke, Questions to Ask Your Doctor After Having a Blood Clot, NBCA Atrial Fibrillation Awareness Survey, Impact of Blood Clots in the Black Community Research Opportunities, NBCA Sports & Wellness Institute: Team Stop the Clot, Council of Emerging Researchers in Thrombosis (CERT), Medical & Scientific Advisory Board (MASAB), not enough clotting power leads to bleeding problems, too much clotting power can lead to the formation of dangerous blood clots. What types of side effects can I expect from the medication? Last reviewed by a Cleveland Clinic medical professional on 09/28/2021. Wear compression stockings if your provider prescribes them for you. What measures are in place to protect my privacy? Factor V Leiden This results from a genetic change that increases the risk of blood clots, especially in deep veins. 04 March 2023. What are my risks? Mayo Clinic is a not-for-profit organization. Some research suggests that women with the Factor V Leiden gene who have had pregnancy losses may have a greater risk of miscarriages. Individuals who happen to know that they have factor V Leiden but have never had blood clots dont have to be prescribed any blood thinners. You must do the 25-minute 5-Factor workout five days a week. Factor V Leiden is an inherited disorder. Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: Advertisement 1. Chan School of Public Health. A family history of factor V Leiden increases your risk of inheriting the disorder. Mayo Clinic does not endorse companies or products. "Anticoagulant Food-Drug Interactions". Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater. Its also important to talk to your provider: Seek emergency medical care if you develop symptoms of deep vein thrombosis or a pulmonary embolism. A food-drug interaction is when a particular food or drink affects the way in which a certain medication works. 76 28 These include deep vein thrombosis, factor V Leiden, myocardial infarction, and polycythemia vera, among many others. This test looks at how quickly the blood clots. This will help to avoid miscarriage or pregnancy complications for the following reasons: . News-Medical. Instead, they have an different form called Factor V Leiden. Try to build up to 150 minutes of moderate-intensity. In general, you should avoid: You can help lower your risk of blood clots with lifestyle changes, including: Visit your provider for a yearly checkup. 2. Heart-healthy foods help reduce inflammation and may help you get to a healthy weight, both of which are necessary for healthy blood, per Johns Hopkins Medicine. Zoppi, Lois. An INR value of 1.1 or below is considered normal in healthy patients, with lower values indicating faster clotting, while higher values show slower clotting rate. This is why Factor V Leiden is sometimes called Activated Protein C Resistance and why people with this mutation clot more than those without it. The need (or not) to wear graded elastic compression stockings during long-haul flights and long road trips. 1-ranked heart program in the United States. Effective measures to eliminate or reduce other risk factors for DVT or PE, such as smoking cessation, weight loss and having a more active lifestyle. 2. Factor V and other proteins work together to help your blood clot when necessary. This is caused by a change (mutation) in the gene for this protein. You should either contact your provider or go to the nearest Emergency Room if you think youre having a deep vein thrombosis. By continuing to browse this site you agree to our use of cookies. That means only one of your parents has to pass the genetic mutation on to you in order for you to inherit it. They were hot, red, and huge. 0000001440 00000 n Deficiencies of antithrombin and proteins C/S, elevated fibrinogen levels, and other clotting disorders also raise risk. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Be active in ways you enjoy. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. The factor V Leiden mutation itself doesnt have any specific treatment. As a result, factor V works in overdrive, making your blood more likely to clot when it shouldnt. 0000236831 00000 n Though scientific research on The 5-Factor Diet is lacking, the plan uses sound nutrition principles of healthy eating and weight loss. 0000002579 00000 n Enjoy a variety of foods from the 4 food groups. Learn more about symptoms, risk factors, causes, diagnosis, treatment, complications, and outlook . Mayo Clinic, Rochester, Minn. June 17, 2018. We do not endorse non-Cleveland Clinic products or services. Take your questions to your healthcare provider and get the answers you need. There is no specific treatment for the mutation itself. %%EOF Though exercise is an important part of the 5-Factor Diet, the recommended amount falls a bit short of the 150 minutes a week of aerobic activity coupled with strength training that most experts recommend. Please note that medical information found Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. The majority of people born with this mutation will not develop an abnormal blood clot in their lifetime. Make a donation. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. It is not a disease. Each 5-Factor five-ingredient meal must include all five must-have food groups: The 5-Factor Diet doesnt mention alcohol specifically, but on the diets cheat day you may eat or drink anything you like. Factor V Leiden is also known under its other name Factor V Leiden Thrombophilia. Late in my pregnancy I started having horrible swelling in my legs. If youve had a deep vein thrombosis or pulmonary embolism before and know you have the prothrombin gene mutation, you may need a prescription for low-dose (preventive doses) of an injectable blood thinner (such as heparin or a low-molecular-weight heparin) during your pregnancy and for a few weeks after delivery. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Foods to limit when you're following a heart-healthy diet include: 1. Dont buy ones from the store or wear them without talking to your provider first. Or maybe youve had no issues, but your loved one needed treatment for DVT. Factor V Leiden. But you will have to be very organized and motivated to stay on track. National Library of Medicines list Two components of the plan, lower GI foods and smaller, more frequent meals, are both known to keep the blood sugar at a lower level, but the amount of carbohydrates would have to be tailored to your own diabetes treatment plan. Factor V Leiden and activated protein C resistance. Our mission of spreading lifesaving #bloodclot awareness is possible thanks to the generous support of our partners. When anticoagulants are prescribed, a prothrombin time (PT) test is used to evaluate its effectiveness. Its important to talk to your provider about any concerns you have related to life expectancy or future complications. Blood clots in the deep veins in your legs (called deep vein thrombosis or DVT) or in your lungs (called pulmonary embolus or PE) can be dangerous. 0000000016 00000 n .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits, Compilation of the top interviews, articles, and news in the last year. Heterozygous Factor V Leiden If you inherited one Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. This gene carries instructions that tell your body how to properly create the factor V protein. It increases the chances that your blood will form abnormal blood clots that can be dangerous. This may not be a good choice for those who have to travel a lot for work, have an inflexible schedule, or prefer to eat out, as food prep and timing may be a problem. The liver is responsible for breaking down alcohol and some medications, and this may cause a slower than normal metabolism of the anticoagulant, increasing the drug concentration in the blood, and hence the risk of bleeding. while also discussing the various products Sartorius produces in order to aid in this. 3. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. This type of medicine usually isn't needed for people who have the factor V Leiden mutation but who have not experienced abnormal blood clots. Tips on transitioning to a whole food fertility diet. The factor V Leiden mutation itself doesnt cause any symptoms. Will Eating More Protein Help Your Body Gain Muscle Faster? Deep venous thrombosis (DVT). 9th ed. Symptoms of a deep vein thrombosis or pulmonary embolism typically start getting better soon after specific treatment is started. With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. Calorie counting is not a feature of this diet plan. You inherited one Factor V Leiden gene from your mother and one from your father. Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This content does not have an Arabic version. If you get the mutation from one of your parents, you are heterozygous (you have only one abnormal copy of the Factor II gene, but the gene from your other parent is normal). Depending on the severity of symptoms, other treatments may be necessary as well. Its important to learn the symptoms so you can seek immediate medical care. Can the results of the test affect my ability to obtain health insurance? Vitamin K is necessary for making the proteins that aid in blood clotting, according to the Harvard T.H. AskMayoExpert. How does prothrombin gene mutation affect my body? 3. However, it is often advised to avoid foods high in Vitamin K. Below is a list of foods that should be avoided because of their . A genetic mutation (change) causes factor V Leiden. https://www.uptodate.com/contents/search. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. That's important because high blood pressure can damage blood vessels, increasing blood clot risk. Chan School of Public Health. Does It Allow for Dietary Restrictions or Preferences? 2005 - 2023 WebMD LLC. However, the disorder raises your risk compared to people without the disorder. Talk to your provider to see if you should be taking a blood thinner. Creator and celebrity fitness trainer Harley Pasternak says it's a lifestyle plan, not a diet. Symptoms may resolve within days or months, depending on the location and severity of your deep vein thrombosis or pulmonary embolism. A single copy of these materials may be reprinted for noncommercial personal use only. U.S. National Institutes of Health, National Human Genome Research Institute. Results from the PT test are expressed as a ratio called the international normalized ratio (INR). Avoid smoking, vaping and tobacco use. You may inherit an abnormal Factor II gene from one or both parents. >_IJ9D/\KwrokzHI7lw7B+Vefcr2L`/R6:s#oI`HlG&W|Az_hSafLG*!~?k{Xi|2`7Q\GcLb9'I |./(-k$Bw&uooR`";j$6GKE:t.0V* II'LX2Q074H4bXh. 3&&}o#Rf,M%>i_+23#_~Ub7{1e9O6I@iQ>,L8?@e"XFExot!^>P(@|` 9 ;90{7,N9|Xf@68-VQBaqL8E-u^5iT Id9l'U"ec BW">)W#idirh#Z>w(!($|1Pa_-780 E71>CCJ8VF}mAGLS!qqEb3 1AEd 'DG/syWtbhF#'. Yes, you can pass on the gene for this disorder to your children. If you are homozygous, you will pass the mutation on to your children. But some people inherit mutated versions of this gene and develop a condition called factor V Leiden thrombophilia. What can I do to support a healthy pregnancy? Prothrombin G20210A (Factor II Mutation) Resources. On the other hand, chronic alcohol consumption reduces the INR. You should not rely on the information provided as a substitute for actual professional medical What are my treatment options if a mutation is found? The sooner you receive care, the better your chances of a good outcome. 0000002423 00000 n Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. If you are heterozygous, theres a 50% chance that your children will get the mutation. Cooking and shopping: Youll spend minimal time and effort on cooking if you stock your refrigerator and pantry with Pasternaks top picks for 5-Factor foods. Last reviewed by a Cleveland Clinic medical professional on 10/04/2022. Cleveland Clinic is a non-profit academic medical center. Cranberry juice and other cranberry products can alter the effects of anticoagulants. About 1 of every 250 Black people in America has the prothrombin gene mutation. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). You may never get a dangerous clot, but its helpful to know the warning signs in case you do. I was placed on maternity leave and put on bed rest. 0000006951 00000 n This caution also extends to drug-food interactions. The factor V Leiden mutation does not itself cause any symptoms. Most people with factor V Leiden never develop abnormal clots. Do you recommend genetic testing for any of my family members? Kaushansky K, et al., eds. If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant. Why? Vitamin K is found in the following foods: Flaxseed may inhibit the proper absorption of anticoagulants. High-Protein Diets -- Do They Really Work? The Meat Effect: Protein, Carbs, and Your Diet. This content does not have an English version. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. Follow Canadas Physical Activity Guide. Factors that increase this risk include: Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). Symptoms of deep vein thrombosis in your arm or leg include: Symptoms of a pulmonary embolism (located in your lung) include: It is a genetic mutation in your Factor II gene that makes it create too much prothrombin (coagulation factor II), and you end up with a higher risk of developing blood clots than someone with a normal prothrombin gene. If you inherited 1 Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. The nutrient can interact with blood-thinning meds, but the idea is not to avoid foods high in vitamin K, like broccoli, kale, spinach and collard greens. Youll spend roughly the same amount on groceries if you keep the bulk of your protein purchases to eggs, lean meats and poultry, and fat-free dairy, as opposed to seafood. If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Avoid playing contact sports or engaging in other activities that could result in physical injury. Current management strategies involve the use of pharmacotherapy, when indicated, in the event of deep venous thrombosis or pulmonary embolism. 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Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. News-Medical.Net provides this medical information service in accordance The clot remains in place while other enzymes repair the damaged blood vessel. This gene is responsible for aiding in normal blood clotting. The different gene that makes the Factor V Leiden protein is inherited from one or both parents. If you are overweight or obese, consider the benefits of losing weight. It is important to discuss potential interactions between existing and new medications to prevent or recognize any side effects. Larger than normal veins near your skins surface. Blood clots can cause serious problems in your body when they block blood flow, keeping oxygen from getting to your cells. ABSTRACT: Factor V Leiden thrombophilia is a genetic disorder that may increase a patient's risk of developing a venous thromboembolism (VTE). Venous thromboembolism. Youll have the prothrombin gene mutation for life, since its part of your genetic makeup. Inherited thrombophilias in pregnancy. This helps your mood and gives you energy all day long. Self-care therapies to support your reproductive health; Before becoming pregnant, talk with your doctor about how your risk of blood clots can be managed during pregnancy, childbirth and for 6 weeks postpartum. Other things can add to your blood clot risk, including: Youll need a specific blood test to check for the prothrombin gene mutation. www.phac-aspc.gc.ca/pau-uap/paguide/. But if you have a blood clotting disorder, your blood forms clots more easily than normal. The best diet to follow is one full of foods that support heart health, because these are also naturally good for your blood health. The plan depends on exercise as much as diet. News-Medical. A mutation in your F5 gene causes this disorder, which follows an autosomal dominant inheritance pattern. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. 5. Both men and women can have factor V Leiden. What can I do to help prevent blood clots from forming? Accessed June 4, 2018. There are no pre-made foods or supplements to buy. Some people do not have the normal Factor V protein. Is an uncertain result possible, and what would that mean? Owned and operated by AZoNetwork, 2000-2023. Lockwood CJ, et al. When taken with anticoagulants, binge-drinking alcohol can increase INR values. With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. On a long flight, take regular walks down the aisles of the plane. Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. https://www.uptodate.com/contents/search. Stand up and walk around during long flights. The questions may keep coming, and thats normal. 0000003332 00000 n Zoppi, Lois. A cough that produces bloody or blood-streaked sputum. Camomile in large quantities, a herbal treatment that is used to treat anxiety, catarrh and gastric problems, has also been implicated in a case of severe bleeding in a 70-year-old woman. In a healthy individual who is bleeding, platelets and clotting factors or specific proteins form a clot to stop the bleeding. But the plan would have to be modified to make it appropriate if you have these or other conditions. If you want to increase the amount you're eating, your doctor can help you make the adjustment slowly, with appropriate adjustments to your medication. Diseasemaps 2023, FACTORV LEIDEN AND LIVEDOID VASCULOPATHY SURVIVOR. Healthy fat (from fish such as salmon, tuna, mackerel, sardines, rainbow trout, or peanut oil, olive oil, canola oil, sunflower oil, Sugar-free drinks (water, sugar-free soda, coffee, tea, or an unsweetened energy drink). This happens because your body makes more of the Factor II (prothrombin) protein than you need for normal clot formation. The American Heart Association cites the following as risk factors for blood clots: 5 Symptoms of a Blood Clot You Should Know. In addition, this mutation only increases the risk of vein clots (deep vein thrombosis or pulmonary embolism). DVT or a PE soon after starting birth control pills or hormone therapy. If you get the mutation from both of your parents, you are homozygous (you have two abnormal copies of the Factor II gene). A single copy of these materials may be reprinted for noncommercial personal use only. However, most people with this genetic mutation never develop these complications. When you need health care or go to the hospital, tell your healthcare team that you have Factor V Leiden, so that they can plan the care you need. Accessed June 4, 2018. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. trailer Factor V Leiden thrombophilia. If youcannot reach your doctor, go to the nearest hospital emergency room. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Bauer KA. A prothrombin gene mutation can raise your risk of getting a pulmonary embolism or deep venous thrombosis. 0 Take frequent breaks during long car rides to get out and stretch your legs. Check with your doctor or dietitian first. But your provider can help you keep your blood from clotting too much. If excess vitamin K is taken, it is stored for future use in the liver. If you inherited 2 Factor V Leiden genes, you have the homozygous type of Factor V Leiden. A. How long do I need to take the anticoagulant? If you have the homozygous type, your child will inherit a Factor V Leiden gene. U.S. National Institutes of Health, National Library of Medicine. The disorder is most common in people who are white and of European descent. Philadelphia, PA 19182-5687.